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KMID : 1044320190210020108
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Annals of Clinical Neurophysiology
2019 Volume.21 No. 2 p.108 ~ p.112
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Paraneoplastic demyelination in the brain presenting as a clinically occult non-Hodgkin’s lymphoma
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Son Hyo-Shin
Choi Jong-Suk
Kim Sung-Un
Park Kyung-Seok
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Abstract
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Non-Hodgkin’s lymphoma (NHL) may initially present with atypical neurological manifestations, including paraneoplastic neurological syndromes. Herein, we report the case showing an initial manifestation of systemic NHL with paraneoplastic demyelination in the brain that initially mimicked the symptoms of stroke, seizure, and brain tumor. A high index of suspicion and timely diagnostic workup is required to prevent diagnostic delay and commence proper management of the condition. In this situation, a whole-body FDG PET/CT could be useful to screen for occult malignancy.
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KEYWORD
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Paraneoplastic syndrome, Occult malignancy, Demyelinating diseases, Non-Hodgkin lymphoma, Diffuse large B-cell lymphoma
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